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Coordinator:
PD Dr. Stefan Wiemann
German Cancer Research Center
Im Neuenheimer Feld 580
69120 Heidelberg
Germany
Phone: +49 6221 42 4646




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Publications

  1. Yamasaki, C., Murakami, K., Fujii, Y., Sato, Y., Harada, E., Takeda, J., Taniya, T., Sakate, R., Kikugawa, S., Shimada, M., Tanino, M., Koyanagi, K. O., Barrero, R. A., Gough, C., Chun, H. W., Habara, T., Hanaoka, H., Hayakawa, Y., Hilton, P. B., Kaneko, Y., Kanno, M., Kawahara, Y., Kawamura, T., Matsuya, A., Nagata, N., Nishikata, K., Noda, A. O., Nurimoto, S., Saichi, N., Sakai, H., Sanbonmatsu, R., Shiba, R., Suzuki, M., Takabayashi, K., Takahashi, A., Tamura, T., Tanaka, M., Tanaka, S., Todokoro, F., Yamaguchi, K., Yamamoto, N., Okido, T., Mashima, J., Hashizume, A., Jin, L., Lee, K. B., Lin, Y. C., Nozaki, A., Sakai, K., Tada, M., Miyazaki, S., Makino, T., Ohyanagi, H., Osato, N., Tanaka, N., Suzuki, Y., Ikeo, K., Saitou, N., Sugawara, H., O'Donovan, C., Kulikova, T., Whitfield, E., Halligan, B., Shimoyama, M., Twigger, S., Yura, K., Kimura, K., Yasuda, T., Nishikawa, T., Akiyama, Y., Motono, C., Mukai, Y., Nagasaki, H., Suwa, M., Horton, P., Kikuno, R., Ohara, O., Lancet, D., Eveno, E., Graudens, E., Imbeaud, S., Debily, M. A., Hayashizaki, Y., Amid, C., Han, M., Osanger, A., Endo, T., Thomas, M. A., Hirakawa, M., Makalowski, W., Nakao, M., Kim, N. S., Yoo, H. S., De Souza, S. J., Bonaldo Mde, F., Niimura, Y., Kuryshev, V., Schupp, I., Wiemann, S., Bellgard, M., Shionyu, M., Jia, L., Thierry-Mieg, D., Thierry-Mieg, J., Wagner, L., Zhang, Q., Go, M., Minoshima, S., Ohtsubo, M., Hanada, K., Tonellato, P., Isogai, T., Zhang, J., Lenhard, B., Kim, S., Chen, Z., Hinz, U., Estreicher, A., Nakai, K., Makalowska, I., Hide, W., Tiffin, N., Wilming, L., Chakraborty, R., Soares, M. B., Chiusano, M. L., Suzuki, Y., Auffray, C., Yamaguchi-Kabata, Y., Itoh, T., Hishiki, T., Fukuchi, S., Nishikawa, K., Sugano, S., Nomura, N., Tateno, Y., Imanishi, T., Gojobori, T., (2008) The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts. Nucleic Acids Res, 36:D793-9
     link to pubmed

  2. Sauermann, M., Sahin, O., Sultmann, H., Hahne, F., Blaszkiewicz, S., Majety, M., Zatloukal, K., Fuzesi, L., Poustka, A., Wiemann, S., Arlt, D., (2008) Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells. Oncogene, 27:1320-6
     link to pubmed

  3. Sansone, S. A., Rocca-Serra, P., Brandizi, M., Brazma, A., Field, D., Fostel, J., Garrow, A. G., Gilbert, J., Goodsaid, F., Hardy, N., Jones, P., Lister, A., Miller, M., Morrison, N., Rayner, T., Sklyar, N., Taylor, C., Tong, W., Warner, G., Wiemann, S., (2008) The First RSBI (ISA-TAB) Workshop: "Can a Simple Format Work for Complex Studies?". Omics, :
     link to pubmed

  4. Retz, W., Rosler, M., Kissling, C., Wiemann, S., Hunnerkopf, R., Coogan, A., Thome, J., Freitag, C., (2008) Norepinephrine transporter and catecholamine-O-methyltransferase gene variants and attention-deficit/hyperactivity disorder symptoms in adults. Journal of Neural Transmission, 115:323-9
     link to pubmed

  5. Mathivanan, S., Ahmed, M., Ahn, N. G., Alexandre, H., Amanchy, R., Andrews, P. C., Bader, J. S., Balgley, B. M., Bantscheff, M., Bennett, K. L., Bjorling, E., Blagoev, B., Bose, R., Brahmachari, S. K., Burlingame, A. S., Bustelo, X. R., Cagney, G., Cantin, G. T., Cardasis, H. L., Celis, J. E., Chaerkady, R., Chu, F., Cole, P. A., Costello, C. E., Cotter, R. J., Crockett, D., DeLany, J. P., De Marzo, A. M., DeSouza, L. V., Deutsch, E. W., Dransfield, E., Drewes, G., Droit, A., Dunn, M. J., Elenitoba-Johnson, K., Ewing, R. M., Van Eyk, J., Faca, V., Falkner, J., Fang, X., Fenselau, C., Figeys, D., Gagne, P., Gelfi, C., Gevaert, K., Gimble, J. M., Gnad, F., Goel, R., Gromov, P., Hanash, S. M., Hancock, W. S., Harsha, H. C., Hart, G., Hays, F., He, F., Hebbar, P., Helsens, K., Hermeking, H., Hide, W., Hjerno, K., Hochstrasser, D. F., Hofmann, O., Horn, D. M., Hruban, R. H., Ibarrola, N., James, P., Jensen, O. N., Jensen, P. H., Jung, P., Kandasamy, K., Kheterpal, I., Kikuno, R. F., Korf, U., Korner, R., Kuster, B., Kwon, M. S., Lee, H. J., Lee, Y. J., Lefevre, M., Lehvaslaiho, M., Lescuyer, P., Levander, F., Lim, M. S., Lobke, C., Loo, J. A., Mann, M., Martens, L., Martinez-Heredia, J., McComb, M., McRedmond, J., Mehrle, A., Menon, R., Miller, C. A., Mischak, H., Mohan, S. S., Mohmood, R., Molina, H., Moran, M. F., Morgan, J. D., Moritz, R., Morzel, M., Muddiman, D. C., Nalli, A., Navarro, J. D., Neubert, T. A., Ohara, O., Oliva, R., Omenn, G. S., Oyama, M., Paik, Y. K., Pennington, K., Pepperkok, R., Periaswamy, B., Petricoin, E. F., Poirier, G. G., Prasad, T. S., Purvine, S. O., Rahiman, B. A., Ramachandran, P., Ramachandra, Y. L., Rice, R. H., Rick, J., Ronnholm, R. H., Salonen, J., Sanchez, J. C., Sayd, T., Seshi, B., Shankari, K., Sheng, S. J., Shetty, V., Shivakumar, K., Simpson, R. J., Sirdeshmukh, R., Siu, K. W., Smith, J. C., Smith, R. D., States, D. J., Sugano, S., Sullivan, M., Superti-Furga, G., Takatalo, M., Thongboonkerd, V., Trinidad, J. C., Uhlen, M., Vandekerckhove, J., Vasilescu, J., Veenstra, T. D., Vidal-Taboada, J. M., Vihinen, M., Wait, R., Wang, X., Wiemann, S., Wu, B., Xu, T., Yates, J. R., Zhong, J., Zhou, M., Zhu, Y., Zurbig, P., Pandey, A., (2008) Human Proteinpedia enables sharing of human protein data. Nature Biotechnology, 26:164-7
     link to pubmed

  6. Lobke, C., Laible, M., Rappl, C., Ruschhaupt, M., Sahin, O., Arlt, D., Wiemann, S., Poustka, A., Sultmann, H., Korf, U., (2008) Contact spotting of protein microarrays coupled with spike-in of normalizer protein permits time-resolved analysis of ERBB receptor signaling. Proteomics, 8:1586-94
     link to pubmed

  7. Kohl, T., Schmidt, C., Wiemann, S., Poustka, A., Korf, U., (2008) Automated production of recombinant human proteins as resource for proteome research. Proteome Sci, 6:4
     link to pubmed

  8. Kissling, C., Retz, W., Wiemann, S., Coogan, A. N., Clement, R. M., Hunnerkopf, R., Conner, A. C., Freitag, C. M., Rosler, M., Thome, J., (2008) A polymorphism at the 3'-untranslated region of the CLOCK gene is associated with adult attention-deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet, 147:333-8
     link to pubmed

  9. Hahne, F, Mehrle, A, Arlt, D. H., Poustka, A, Wiemann, S, Beissbarth, T., (2008) Extending pathways based on gene lists using InterPro domain signatures. BMC Bioinformatics, 9:3
     link to pubmed

  10. Yudushkin, I. A., Schleifenbaum, A., Kinkhabwala, A., Neel, B. G., Schultz, C., Bastiaens, P. I., (2007) Live-cell imaging of enzyme-substrate interaction reveals spatial regulation of PTP1B. Science, 315:115-9
     link to pubmed

  11. Simpson, J. C., Mateos, A., Pepperkok, R., (2007) Maturation of the mammalian secretome. Genome Biology, 8:211
     link to pubmed

  12. Simpson, J. C., Cetin, C., Erfle, H., Joggerst, B., Liebel, U., Ellenberg, J., Pepperkok, R., (2007) An RNAi screening platform to identify secretion machinery in mammalian cells. Journal of Biotechnology, 129:352-65
     link to pubmed

  13. Sauermann, M, Hahne, F, Schmidt, C, Majety, M, Rosenfelder, H, Bechtel, S, Huber, W, Poustka, A, Arlt, D, Wiemann, S, (2007) High throughput FACS based assay to identify apoptosis inducing proteins. J. Biomol Screening, 12:510-520
     link to pubmed

  14. Sahin, O., Löbke, C., Korf, U., Sultmann, H., Poustka, A., Wiemann, S., Arlt, D., (2007) Combinatorial RNAi strategy: The next generation of quantitative protein network analysis. Proc Natl Acad Sci U S A, 104:6579-6584
     link to pubmed

  15. Retz, W., Rosler, M., Kissling, C., Wiemann, S., Hunnerkopf, R., Coogan, A., Thome, J., Freitag, C., (2007) Norepinephrine transporter and catecholamine-O-methyltransferase gene variants and attention-deficit/hyperactivity disorder symptoms in adults. Journal of Neural Transmission, :
     link to pubmed

  16. Loebke, C., Sueltmann, H., Schmidt, C., Henjes, F., Wiemann, S., Poustka, A., Korf, U., (2007) Infrared-based protein detection arrays for quantitative proteomics. Proteomics, 7:558-564
     link to pubmed

  17. Laketa, V., Simpson, J. C., Bechtel, S., Wiemann, S., Pepperkok, R., (2007) High-Content Microscopy Identifies New Neurite Outgrowth Regulators. Molecular Biology of the Cell, 18:242-252
     link to pubmed

  18. Kissling, C., Retz, W., Wiemann, S., Coogan, A. N., Clement, R. M., Hunnerkopf, R., Conner, A. C., Freitag, C. M., Rosler, M., Thome, J., (2007) A polymorphism at the 3'-untranslated region of the CLOCK gene is associated with adult attention-deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet, :
     link to pubmed

  19. Erfle, H., Pepperkok, R., (2007) Production of siRNA- and cDNA-transfected cell arrays on noncoated chambered coverglass for high-content screening microscopy in living cells. Methods in Molecular Biology, 360:155-61
     link to pubmed

  20. Erfle, H., Neumann, B., Liebel, U., Rogers, P., Held, M., Walter, T., Ellenberg, J., Pepperkok, R., (2007) Reverse transfection on cell arrays for high content screening microscopy. Nat Protoc, 2:392-9
     link to pubmed

  21. Bechtel, S., Rosenfelder, H., Duda, A., Schmidt, C. P., Ernst, U., Wellenreuther, R., Mehrle, A., Schuster, C., Bahr, A., Blocker, H., Heubner, D., Hoerlein, A., Michel, G., Wedler, H., Kohrer, K., Ottenwalder, B., Poustka, A., Wiemann, S., Schupp, I., (2007) The full-ORF clone resource of the German cDNA Consortium. BMC Genomics, 8:399
     link to pubmed

  22. Verissimo, F., Silva, E., Morris, J. D., Pepperkok, R., Jordan, P., (2006) Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway. Oncogene, 25:4172-82
     link to pubmed

  23. Treutlein, J., Kissling, C., Frank, J., Wiemann, S., Dong, L., Depner, M., Saam, C., Lascorz, J., Soyka, M., Preuss, U. W., Rujescu, D., Skowronek, M. H., Rietschel, M., Spanagel, R., Heinz, A., Laucht, M., Mann, K., Schumann, G., (2006) Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples. Molecular Psychiatry, 11:594-602
     link to pubmed

  24. Takeda, J., Suzuki, Y., Nakao, M., Barrero, R. A., Koyanagi, K. O., Jin, L., Motono, C., Hata, H., Isogai, T., Nagai, K., Otsuki, T., Kuryshev, V., Shionyu, M., Yura, K., Go, M., Thierry-Mieg, J., Thierry-Mieg, D., Wiemann, S., Nomura, N., Sugano, S., Gojobori, T., Imanishi, T., (2006) Large-scale identification and characterization of alternative splicing variants of human gene transcripts using 56,419 completely sequenced and manually annotated full-length cDNAs. Nucleic Acids Res, 34:3917-28
     link to pubmed

  25. Tabary, O., Boncoeur, E., de Martin, R., Pepperkok, R., Clement, A., Schultz, C., Jacquot, J., (2006) Calcium-dependent regulation of NF-(kappa)B activation in cystic fibrosis airway epithelial cells. Cellular Signalling, 18:652-660
     link to pubmed

  26. Stauber, T., Simpson, J. C., Pepperkok, R., Vernos, I., (2006) A Role for Kinesin-2 in COPI-Dependent Recycling between the ER and the Golgi Complex. Current Biology, 16:2245-51
     link to pubmed

  27. Simpson, J. C., Pepperkok, R., (2006) The subcellular localization of the mammalian proteome comes a fraction closer. Genome Biology, 7:222
     link to pubmed

  28. Simpson, J. C., Nilsson, T., Pepperkok, R., (2006) Biogenesis of Tubular ER-to-Golgi Transport Intermediates. Molecular Biology of the Cell, 17:723-37
     link to pubmed

  29. Seiler, M., Mehrle, A., Poustka, A., Wiemann, S., (2006) The 3of5 web application for complex and comprehensive pattern matching in protein sequences. BMC Bioinformatics, 7:144
     link to pubmed

  30. Runz, H., Miura, K., Weiss, M., Pepperkok, R., (2006) Sterols regulate ER-export dynamics of secretory cargo protein ts-O45-G. EMBO Journal, 25:2953-65
     link to pubmed

  31. Rocks, O., Peyker, A., Bastiaens, P. I., (2006) Spatio-temporal segregation of Ras signals: one ship, three anchors, many harbors. Current Opinion in Cell Biology, 18:351-7
     link to pubmed

  32. Rattei, T., Arnold, R., Tischler, P., Lindner, D., Stumpflen, V., Mewes, H. W., (2006) SIMAP: the similarity matrix of proteins. Nucleic Acids Res, 34:D252-6
     link to pubmed

  33. Pepperkok, R., Ellenberg, J., (2006) High-throughput fluorescence microscopy for systems biology. Nature Reviews Molecular and Cellular Biology, 7:690-696
     link to pubmed

  34. Orchard, S., Apweiler, R., Barkovich, R., Field, D., Garavelli, J. S., Horn, D., Jones, A., Jones, P., Julian, R., McNally, R., Nerothin, J., Paton, N., Pizarro, A., Seymour, S., Taylor, C., Wiemann, S., Hermjakob, H., (2006) Proteomics and Beyond A report on the 3(rd) Annual Spring Workshop of the HUPO-PSI 21-23 April 2006, San Francisco, CA, USA. Proteomics, 6:4439-4443
     link to pubmed

  35. Neumann, B., Held, M., Liebel, U., Erfle, H., Rogers, P., Pepperkok, R., Ellenberg, J., (2006) High-throughput RNAi screening by time-lapse imaging of live human cells. , 3:385-90
     link to pubmed

  36. Mewes, H. W., Frishman, D., Mayer, K. F., Munsterkotter, M., Noubibou, O., Pagel, P., Rattei, T., Oesterheld, M., Ruepp, A., Stumpflen, V., (2006) MIPS: analysis and annotation of proteins from whole genomes in 2005. Nucleic Acids Res, 34:D169-72
     link to pubmed

  37. Mehrle, A., Rosenfelder, H., Schupp, I., Del Val, C., Arlt, D., Hahne, F., Bechtel, S., Simpson, J., Hofmann, O., Hide, W., Glatting, K. H., Huber, W., Pepperkok, R., Poustka, A., Wiemann, S., (2006) The LIFEdb database in 2006. Nucleic Acids Res, 34:D415-8
     link to pubmed

  38. Kuryshev, V. Y., Vorobyov, E., Zink, D., Schmitz, J., Rozhdestvensky, T. S., Munstermann, E., Ernst, U., Wellenreuther, R., Moosmayer, P., Bechtel, S., Schupp, I., Horst, J., Korn, B., Poustka, A., Wiemann, S., (2006) An anthropoid-specific segmental duplication on human chromosome 1q22. Genomics, 88:143-51
     link to pubmed

  39. Kolb-Kokocinski, A., Mehrle, A., Bechtel, S., Simpson, J. C., Kioschis, P., Wiemann, S., Wellenreuther, R., Poustka, A., (2006) The systematic functional characterisation of Xq28 genes prioritises candidate disease genes. BMC Genomics, 7:29
     link to pubmed

  40. Hahne, F, Arlt, D, Sauermann, M, Majety, M, Poustka, A, Wiemann, S, Huber, W, (2006) Statistical methods and software for the analysis of high-throughput reverse genetic assays using flow cytometry readouts. Genome Biology, 7:R77
     link to pubmed

  41. Gentleman, R., Hahne, F., Huber, W., (2006) Visualizing Genomic Data. , Working Paper 10:
     link to pubmed

  42. Forster, R., Weiss, M., Zimmermann, T., Reynaud, E. G., Verissimo, F., Stephens, D. J., Pepperkok, R., (2006) Secretory Cargo Regulates the Turnover of COPII Subunits at Single ER Exit Sites. Current Biology, 16:173-9
     link to pubmed

  43. Fleischer, S., Wiemann, S., Will, H., Hofmann, T. G., (2006) PML-associated repressor of transcription (PAROT), a novel KRAB-zinc finger repressor, is regulated through association with PML nuclear bodies. Experimental Cell Research, 312:901-12
     link to pubmed

  44. Erfle, H., Pepperkok, R., (2006) Production of siRNA- and cDNA-Transfected Cell Arrays on Noncoated Chambered Coverglass for High-Content Screening Microscopy in Living Cells. Methods in Molecular Biology, 360:155-62
     link to pubmed

  45. del Val, C., Kuryshev, V. Y., Glatting, K. H., Ernst, P., Hotz-Wagenblatt, A., Poustka, A., Suhai, S., Wiemann, S., (2006) CAFTAN: a tool for fast mapping, and quality assessment of cDNAs. BMC Bioinformatics, 7:473
     link to pubmed

  46. Bastiaens, P., Caudron, M., Niethammer, P., Karsenti, E., (2006) Gradients in the self-organization of the mitotic spindle. Trends in Cell Biology, 16:125-34
     link to pubmed

  47. Antonov, A. V., Tetko, I. V., Mewes, H. W., (2006) A systematic approach to infer biological relevance and biases of gene network structures. Nucleic Acids Res, 34:e6
     link to pubmed

  48. Antonov, A. V., Mewes, H. W., (2006) Complex functionality of gene groups identified from high-throughput data. Journal of Molecular Biology, 363:289-96
     link to pubmed

  49. Antonov, A. V., Mewes, H. W., (2006) BIOREL: the benchmark resource to estimate the relevance of the gene networks. FEBS Letters, 580:844-8
     link to pubmed

  50. Young, J., Stauber, T., Del Nery, E., Vernos, I., Pepperkok, R., Nilsson, T., (2005) Regulation of Microtubule-dependent Recycling at the Trans-Golgi Network by Rab6A and Rab6A'. Molecular Biology of the Cell, 16:162-77
     link to pubmed

  51. Yang, Y. D., Elamawi, R., Bubeck, J., Pepperkok, R., Ritzenthaler, C., Robinson, D. G., (2005) Dynamics of COPII Vesicles and the Golgi Apparatus in Cultured Nicotiana tabacum BY-2 Cells Provides Evidence for Transient Association of Golgi Stacks with Endoplasmic Reticulum Exit Sites. Plant Cell, 17:1513-31
     link to pubmed

  52. Wiemann, S., Kolb-Kokocinski, A., Poustka, A., (2005) Alternative pre-mRNA processing regulates cell-type specific expression of the IL4l1 and NUP62 genes. BMC Biology, 3:16
     link to pubmed

  53. Watson, P., Forster, R., Palmer, K. J., Pepperkok, R., Stephens, D. J., (2005) Coupling of ER exit to microtubules through direct interaction of COPII with dynactin. Nat Cell Biol, 7:48-55
     link to pubmed

  54. Wang, Y., Tetko, I. V., Hall, M. A., Frank, E., Facius, A., Mayer, K. F., Mewes, H. W., (2005) Gene selection from microarray data for cancer classification--a machine learning approach. Comput Biol Chem, 29:37-46
     link to pubmed

  55. Tetko, I. V., Facius, A., Ruepp, A., Mewes, H. W., (2005) Super paramagnetic clustering of protein sequences. BMC Bioinformatics, 6:82
     link to pubmed

  56. Sultmann, H., von Heydebreck, A., Huber, W., Kuner, R., Buness, A., Vogt, M., Gunawan, B., Vingron, M., Fuzesi, L., Poustka, A., (2005) Gene expression in kidney cancer is associated with cytogenetic abnormalities, metastasis formation, and patient survival. Clinical Cancer Research, 11:646-55
     link to pubmed

  57. Stelzl, U., Worm, U., Lalowski, M., Haenig, C., Brembeck, F. H., Goehler, H., Stroedicke, M., Zenkner, M., Schoenherr, A., Koeppen, S., Timm, J., Mintzlaff, S., Abraham, C., Bock, N., Kietzmann, S., Goedde, A., Toksoz, E., Droege, A., Krobitsch, S., Korn, B., Birchmeier, W., Lehrach, H., Wanker, E. E., (2005) A human protein-protein interaction network: a resource for annotating the proteome. Cell, 122:957-68
     link to pubmed

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  124. Mannhaupt, G., Montrone, C., Haase, D., Mewes, H. W., Aign, V., Hoheisel, J. D., Fartmann, B., Nyakatura, G., Kempken, F., Maier, J., Schulte, U., (2003) What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence. Nucleic Acids Res, 31:1944-54
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  125. Liebel, U., Starkuviene, V., Erfle, H., Simpson, J. C., Poustka, A., Wiemann, S., Pepperkok, R., (2003) A microscope-based screening platform for large-scale functional protein analysis in intact cells. FEBS Letters, 554:394-8
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  126. Frishman, D., Mokrejs, M., Kosykh, D., Kastenmuller, G., Kolesov, G., Zubrzycki, I., Gruber, C., Geier, B., Kaps, A., Albermann, K., Volz, A., Wagner, C., Fellenberg, M., Heumann, K., Mewes, H. W., (2003) The PEDANT genome database. Nucleic Acids Res, 31:207-11
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  127. Deinsberger, W., Mewes, H., Traupe, H., Boeker, D. K., (2003) Surgical management of previously coiled intracranial aneurysms. British Journal of Neurosurgery, 17:149-54
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  128. Bon, E., Casaregola, S., Blandin, G., Llorente, B., Neuveglise, C., Munsterkotter, M., Guldener, U., Mewes, H. W., Van Helden, J., Dujon, B., Gaillardin, C., (2003) Molecular evolution of eukaryotic genomes: hemiascomycetous yeast spliceosomal introns. Nucleic Acids Res, 31:1121-35
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  129. Zimmermann, T., Rietdorf, J., Girod, A., Georget, V., Pepperkok, R., (2002) Spectral imaging and linear un-mixing enables improved FRET efficiency with a novel GFP2-YFP FRET pair. FEBS Letters, 531:245-9
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  130. Stephens, D. J., Pepperkok, R., (2002) Imaging of procollagen transport reveals COPI-dependent cargo sorting during ER-to-Golgi transport in mammalian cells. Journal of Cell Science, 115:1149-60
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  131. Schulte, U., Becker, I., Mewes, H. W., Mannhaupt, G., (2002) Large scale analysis of sequences from Neurospora crassa. Journal of Biotechnology, 94:3-13
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  132. Runz, H., Rietdorf, J., Tomic, I., de Bernard, M., Beyreuther, K., Pepperkok, R., Hartmann, T., (2002) Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells. Journal of Neuroscience, 22:1679-89
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  133. Richards, A. A., Stang, E., Pepperkok, R., Parton, R. G., (2002) Inhibitors of COP-mediated transport and cholera toxin action inhibit simian virus 40 infection. Molecular Biology of the Cell, 13:1750-64
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  134. Morgenstern, B., Rinner, O., Abdeddaim, S., Haase, D., Mayer, K. F., Dress, A. W., Mewes, H. W., (2002) Exon discovery by genomic sequence alignment. Bioinformatics, 18:777-87
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  135. Mollenhauer, J., Muller, H., Kollender, G., Lyer, S., Diedrichs, L., Helmke, B., Holmskov, U., Ligtenberg, T., Herbertz, S., Krebs, I., Madsen, J., Bikker, F., Schmitt, L., Wiemann, S., Scheurlen, W., Otto, H. F., von Deimling, A., Poustka, A., (2002) The SRCR/SID region of DMBT1 defines a complex multi-allele system representing the major basis for its variability in cancer. Genes, Chromosomes and Cancer, 35:242-55
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  136. Mollenhauer, J., Helmke, B., Muller, H., Kollender, G., Lyer, S., Diedrichs, L., Holmskov, U., Ligtenberg, T., Herbertz, S., Krebs, I., Wiemann, S., Madsen, J., Bikker, F., Schmitt, L., Otto, H. F., Poustka, A., (2002) Sequential changes of the DMBT1 expression and location in normal lung tissue and lung carcinomas. Genes, Chromosomes and Cancer, 35:164-9
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  137. Mollenhauer, J., Helmke, B., Muller, H., Kollender, G., Krebs, I., Wiemann, S., Holmskov, U., Madsen, J., Otto, H. F., Poustka, A., (2002) An integrative model on the role of DMBT1 in epithelial cancer. Cancer Detection and Prevention, 26:266-74
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  138. Mewes, H., Richter, M., (2002) Supplementary ultraviolet-B radiation induces a rapid reversal of the diadinoxanthin cycle in the strong light-exposed diatom Phaeodactylum tricornutum. Plant Physiology, 130:1527-35
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  139. Mayer, K., Mewes, H. W., (2002) How can we deliver the large plant genomes? Strategies and perspectives. Current Opinion in Plant Biology, 5:173-7
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  140. Kolesov, G., Mewes, H. W., Frishman, D., (2002) SNAPper: gene order predicts gene function. Bioinformatics, 18:1017-9
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  141. Haj, F. G., Verveer, P. J., Squire, A., Neel, B. G., Bastiaens, P. I., (2002) Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum. Science, 295:1708-11
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  142. Gruss, O. J., Wittmann, M., Yokoyama, H., Pepperkok, R., Kufer, T., Sillje, H., Karsenti, E., Mattaj, I. W., Vernos, I., (2002) Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells. Nat Cell Biol, 4:871-9
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  143. Frishman, D., Kaps, A., Mewes, H. W., (2002) Online genomics facilities in the new millennium. Pharmacogenomics, 3:265-71
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  144. Coy, J. F., Wiemann, S., Bechmann, I., Bachner, D., Nitsch, R., Kretz, O., Christiansen, H., Poustka, A., (2002) Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms. Gene, 290:73-94
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  145. Wouters, F. S., Verveer, P. J., Bastiaens, P. I., (2001) Imaging biochemistry inside cells. Trends in Cell Biology, 11:203-11
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  146. Wiemann, S., Weil, B., Wellenreuther, R., Gassenhuber, J., Glassl, S., Ansorge, W., Bocher, M., Blocker, H., Bauersachs, S., Blum, H., Lauber, J., Dusterhoft, A., Beyer, A., Kohrer, K., Strack, N., Mewes, H. W., Ottenwalder, B., Obermaier, B., Tampe, J., Heubner, D., Wambutt, R., Korn, B., Klein, M., Poustka, A., (2001) Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome Research, 11:422-35
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  147. Verveer, P. J., Squire, A., Bastiaens, P. I., (2001) Improved spatial discrimination of protein reaction states in cells by global analysis and deconvolution of fluorescence lifetime imaging microscopy data. Journal of Microscopy, 202:451-6
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  148. Stephens, D. J., Pepperkok, R., (2001) The many ways to cross the plasma membrane. Proc Natl Acad Sci U S A, 98:4295-8
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  149. Stephens, D. J., Pepperkok, R., (2001) Illuminating the secretory pathway: when do we need vesicles?. Journal of Cell Science, 114:1053-9
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  150. Simpson, J. C., Neubrand, V. E., Wiemann, S., Pepperkok, R., (2001) Illuminating the human genome. Histochemistry and Cell Biology, 115:23-9
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  151. Pepperkok, R., Simpson, J. C., Wiemann, S., (2001) Being in the right location at the right time. Genome Biology, 2:REVIEWS1024
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  152. Ng, T., Parsons, M., Hughes, W. E., Monypenny, J., Zicha, D., Gautreau, A., Arpin, M., Gschmeissner, S., Verveer, P. J., Bastiaens, P. I., Parker, P. J., (2001) Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility. EMBO Journal, 20:2723-41
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  153. Mollenhauer, J., Herbertz, S., Helmke, B., Kollender, G., Krebs, I., Madsen, J., Holmskov, U., Sorger, K., Schmitt, L., Wiemann, S., Otto, H. F., Grone, H. J., Poustka, A., (2001) Deleted in Malignant Brain Tumors 1 is a versatile mucin-like molecule likely to play a differential role in digestive tract cancer. Cancer Research, 61:8880-6
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  154. Kerkhoff, E., Simpson, J. C., Leberfinger, C. B., Otto, I. M., Doerks, T., Bork, P., Rapp, U. R., Raabe, T., Pepperkok, R., (2001) The Spir actin organizers are involved in vesicle transport processes. Current Biology, 11:1963-8
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  155. Harpur, A. G., Wouters, F. S., Bastiaens, P. I., (2001) Imaging FRET between spectrally similar GFP molecules in single cells. Nature Biotechnology, 19:167-9
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  156. Beyer, K. S., Klauck, S. M., Wiemann, S., Poustka, A., (2001) Construction of a physical map of an autism susceptibility region in 7q32.3-q33. Gene, 272:85-91
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  157. Verveer, P. J., Wouters, F. S., Reynolds, A. R., Bastiaens, P. I., (2000) Quantitative imaging of lateral ErbB1 receptor signal propagation in the plasma membrane. Science, 290:1567-70
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  158. Verveer, P. J., Squire, A., Bastiaens, P. I., (2000) Global analysis of fluorescence lifetime imaging microscopy data. Biophysical Journal, 78:2127-37
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  159. Thullner, S., Gesellchen, F., Wiemann, S., Pyerin, W., Kinzel, V., Bossemeyer, D., (2000) The protein kinase A catalytic subunit Cbeta2: molecular characterization and distribution of the splice variant. Biochemical Journal, 351:123-32
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  160. Storrie, B., Pepperkok, R., Nilsson, T., (2000) Breaking the COPI monopoly on Golgi recycling. Trends in Cell Biology, 10:385-91
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  161. Stephens, D. J., Lin-Marq, N., Pagano, A., Pepperkok, R., Paccaud, J. P., (2000) COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites. Journal of Cell Science, 113 ( Pt 12):2177-85
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  162. Squire, A., Verveer, P. J., Bastiaens, P. I., (2000) Multiple frequency fluorescence lifetime imaging microscopy. Journal of Microscopy, 197 ( Pt 2):136-49
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  163. Smahi, A., Courtois, G., Vabres, P., Yamaoka, S., Heuertz, S., Munnich, A., Israel, A., Heiss, N. S., Klauck, S. M., Kioschis, P., Wiemann, S., Poustka, A., Esposito, T., Bardaro, T., Gianfrancesco, F., Ciccodicola, A., D'Urso, M., Woffendin, H., Jakins, T., Donnai, D., Stewart, H., Kenwrick, S. J., Aradhya, S., Yamagata, T., Levy, M., Lewis, R. A., Nelson, D. L., (2000) Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium. Nature, 405:466-72
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  164. Simpson, J. C., Wellenreuther, R., Poustka, A., Pepperkok, R., Wiemann, S., (2000) Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. EMBO Reports, 1:287-92
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  165. Pepperkok, R., Whitney, J. A., Gomez, M., Kreis, T. E., (2000) COPI vesicles accumulating in the presence of a GTP restricted arf1 mutant are depleted of anterograde and retrograde cargo. Journal of Cell Science, 113 ( Pt 1):135-44
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  166. Pepperkok, R., Hotz-Wagenblatt, A., Konig, N., Girod, A., Bossemeyer, D., Kinzel, V., (2000) Intracellular distribution of mammalian protein kinase A catalytic subunit altered by conserved Asn2 deamidation. Journal of Cell Biology, 148:715-26
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  167. Neil, M. A., Squire, A., Juskaitis, R., Bastiaens, P. I., Wilson, T., (2000) Wide-field optically sectioning fluorescence microscopy with laser illumination. Journal of Microscopy, 197 ( Pt 1):1-4
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  168. Mollenhauer, J., Herbertz, S., Holmskov, U., Tolnay, M., Krebs, I., Merlo, A., Schroder, H. D., Maier, D., Breitling, F., Wiemann, S., Grone, H. J., Poustka, A., (2000) DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer. Cancer Research, 60:1704-10
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  169. Denzel, A., Otto, F., Girod, A., Pepperkok, R., Watson, R., Rosewell, I., Bergeron, J. J., Solari, R. C., Owen, M. J., (2000) The p24 family member p23 is required for early embryonic development. Current Biology, 10:55-8
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  170. Bastiaens, P. I., Pepperkok, R., (2000) Observing proteins in their natural habitat: the living cell. Trends in Biochemical Sciences, 25:631-7
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